An optical minimally invasive theranostic system with multimodal optical diagnosis guided laser ablation for decreasing brain tumor burden

Yingwei Fan; Hongxiang Kang; Hongen Liao

doi:10.1117/12.2575142

10 October 2020 An optical minimally invasive theranostic system with multimodal optical diagnosis guided laser ablation for decreasing brain tumor burden

Yingwei Fan, Hongxiang Kang, Hongen Liao

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Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 115530U (2020) https://doi.org/10.1117/12.2575142
Event: SPIE/COS Photonics Asia, 2020, Online Only

Abstract

Neurosurgery is currently a common solution for decreasing the brain tumor burden, but it relies heavily on surgeons' experience, and intraoperative guidance still cannot be researched. To implement the real-time minimally invasive theranostics of brain tumors, the research on the intraoperative precision diagnosis and therapeutics need to be conducted. Here, we develop an optical minimally invasive theranostics system, which uses multimodal optical image including an optical coherence tomography (OCT), photoacoustic imaging (PAI) to visualize brain tumors, and uses supercontinuum laser to ablate brain tumors. The Fourier domain algorithm is employed to compute the optical attenuation coefficient (OAC) of OCT images for quantitatively identifying the brain cancerous tissue. Furthermore, we design an intelligent reseau-based optical theranostic method to integrate the intraoperative OCT imaging and laser ablation for treating brain tumors in vivo.

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Yingwei Fan, Hongxiang Kang, and Hongen Liao "An optical minimally invasive theranostic system with multimodal optical diagnosis guided laser ablation for decreasing brain tumor burden", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115530U (10 October 2020); https://doi.org/10.1117/12.2575142

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KEYWORDS

Brain

Tumors

Laser ablation

Laser optics

Neuroimaging

Optical coherence tomography

Tissue optics

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