Machine learning applications for spectral analysis of human exhaled breath for early diagnosis of diseases

Igor L. Fufurin; Igor S. Golyak; Dmitriy R. Anfimov; Anastasiya S. Tabalina; Elizaveta R. Kareva; Andrey N. Morozov; Pavel P. Demkin

doi:10.1117/12.2584043

10 October 2020 Machine learning applications for spectral analysis of human exhaled breath for early diagnosis of diseases

Igor L. Fufurin, Igor S. Golyak, Dmitriy R. Anfimov, Anastasiya S. Tabalina, Elizaveta R. Kareva, Andrey N. Morozov, Pavel P. Demkin

Author Affiliations +

Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 115531G (2020) https://doi.org/10.1117/12.2584043
Event: SPIE/COS Photonics Asia, 2020, Online Only

Abstract

In this work, the possibility of using machine learning in the spectral analysis of exhaled breath for early diagnosis of diseases is considered. Experimental setup consists of a quantum cascade laser with a tuning range of 5.4–12.8 μm and Herriot astigmatic gas cell. A shallow convolutional neutral network and principal component analysis is used to identify biomarkers and its mixtures. A minimum detectable concentration for acetone and ethanol at sub-ppm level is obtained for optical path length up to 6 m and signal-to-noise less than 3. It is shown that neural networks in comparison with statistical methods give a lower detection limits for the same signal-to-noise ratio in the measured spectrum.

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Igor L. Fufurin, Igor S. Golyak, Dmitriy R. Anfimov, Anastasiya S. Tabalina, Elizaveta R. Kareva, Andrey N. Morozov, and Pavel P. Demkin "Machine learning applications for spectral analysis of human exhaled breath for early diagnosis of diseases", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115531G (10 October 2020); https://doi.org/10.1117/12.2584043

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