Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: A comparison of colorimetry with Spatial Frequency Domain Imaging

Thinh Phan; Rebecca Rowland; Adrien Ponticorvo; Binh C Le; Robert H. Wilson; Seyed A. Sharif; Gordon T. Kennedy; Anthony J. Durkin

doi:10.1117/12.2576800

5 March 2021 Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: A comparison of colorimetry with Spatial Frequency Domain Imaging

Thinh Phan, Rebecca Rowland, Adrien Ponticorvo, Binh C Le, Robert H. Wilson, Seyed A. Sharif, Gordon T. Kennedy, Anthony J. Durkin

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Proceedings Volume 11618, Photonics in Dermatology and Plastic Surgery 2021; 1161810 (2021) https://doi.org/10.1117/12.2576800
Event: SPIE BiOS, 2021, Online Only

Abstract

Spatial frequency domain imaging (SFDI) is a wide-field spectral imaging technique that can be used to characterize optical properties of in-vivo tissue. Typically, SFDI uses light transport modeling based on Monte Carlo simulations to analyze the detected diffuse reflectance. Here, we examined the effect of using a semi-infinite homogeneous tissue model to determine optical properties of in-vivo human skin across a full range of pigmentation levels. We analyzed µs’ curves and performed correlation analysis between µs’ and degree of pigmentation determined using a tristimulus colorimeter. Our results suggested that pigmentation’s effect on µs’ is minimal at near-infrared wavelengths.

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Thinh Phan, Rebecca Rowland, Adrien Ponticorvo, Binh C Le, Robert H. Wilson, Seyed A. Sharif, Gordon T. Kennedy, and Anthony J. Durkin "Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: A comparison of colorimetry with Spatial Frequency Domain Imaging", Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 1161810 (5 March 2021); https://doi.org/10.1117/12.2576800

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KEYWORDS

Skin

Optical properties

In vivo imaging

Tissue optics

Light wave propagation

Mie scattering

Monte Carlo methods

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