Monitoring cancer cell surface receptor expression during anti-angiogenesis therapy in vivo

Boyu Meng; Rendall R. Strawbridge; Kenneth Tichauer; Kimberley S. Samkoe; Scott C. Davis

doi:10.1117/12.2583237

5 March 2021 Monitoring cancer cell surface receptor expression during anti-angiogenesis therapy in vivo

Boyu Meng, Rendall R. Strawbridge, Kenneth Tichauer, Kimberley S. Samkoe, Scott C. Davis

Proceedings Volume 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII; 116250Q (2021) https://doi.org/10.1117/12.2583237
Event: SPIE BiOS, 2021, Online Only

Abstract

Concurrent administration of cancer therapeutics with tumor vasculature targeting treatment has been shown to improve overall survival in multiple human cancer types, as such combinations aim to destroy different compartments of tumors. Anti-angiogenesis therapeutics designed to inhibit tumor induced vessel sprouting have also been shown to re-model the tumor vasculature through a transient vessel normalization effect, which leads to improved perfusion of oxygen and drug in tumor. However, the effects that this normalized vasculature has on the availability of cancer receptor, such as EGFR, is unknown. Herein, we examined the use of MRI-PAFT to estimate cancer surface receptor availability in response to anti-angiogenesis therapy, using MRI-coupled paired agent fluorescence tomography. Bevacizumab treated tumors showed increase in RA compared to control tumors, but this was not statistically significant.

Conference Presentation

Citation Download Citation

Boyu Meng, Rendall R. Strawbridge, Kenneth Tichauer, Kimberley S. Samkoe, and Scott C. Davis "Monitoring cancer cell surface receptor expression during anti-angiogenesis therapy in vivo", Proc. SPIE 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII, 116250Q (5 March 2021); https://doi.org/10.1117/12.2583237

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available