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5 March 2021 Inactivation and sensitization of middle ear infection related bacteria and biofilm by microplasma jet array
Jungeun Won, Peter P. Sun, Gabrielle Choo-Kang, Shouyan Li, Wenyuan Chen, Guillermo L. Monroy, Eric J. Chaney, J. G. Eden, Thanh H. Nguyen, Stephen A. Boppart
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Proceedings Volume 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021; 116260K (2021) https://doi.org/10.1117/12.2577424
Event: SPIE BiOS, 2021, Online Only
Abstract
A middle ear infection is a prevalent inflammatory disease during childhood, often caused by bacterial pathogens. A portable and replaceable microplasma jet array was developed to investigate the feasibility of inactivating Pseudomonas aeruginosa, a common bacterial strain associated with middle ear infections. Reactive species generated by the non-thermal microplasma jet array inactivated planktonic bacteria and biofilm. A middle ear phantom was developed using the rat eardrum to study the antimicrobial effects on bacteria located behind the eardrum. Lastly, 3D volumetric OCT imaging and histology were performed on the rat eardrum to examine the potential structural changes due to the plasma.
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Jungeun Won, Peter P. Sun, Gabrielle Choo-Kang, Shouyan Li, Wenyuan Chen, Guillermo L. Monroy, Eric J. Chaney, J. G. Eden, Thanh H. Nguyen, and Stephen A. Boppart "Inactivation and sensitization of middle ear infection related bacteria and biofilm by microplasma jet array", Proc. SPIE 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021, 116260K (5 March 2021); https://doi.org/10.1117/12.2577424
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KEYWORDS
Bacteria
Ear
Plasmas
Plasma treatment
Resistance
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