Cherenkov imaging for total skin electron therapy: an evaluation of dose uniformity

Timothy C. Zhu; Yihong Ong; Hongjing Sun; Weili Zhong; Tianshun Miao; Andreea Dimofte; Petr Bruza; Amit Maity; John P. Plastaras; Ima Paydar; Lei Dong; Brian W. Pogue

doi:10.1117/12.2583939

30 March 2021 Cherenkov imaging for total skin electron therapy: an evaluation of dose uniformity

Timothy C. Zhu, Yihong Ong, Hongjing Sun, Weili Zhong, Tianshun Miao, Andreea Dimofte, Petr Bruza, Amit Maity, John P. Plastaras, Ima Paydar, Lei Dong, Brian W. Pogue

Author Affiliations +

Proceedings Volume 11628, Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation; 116280R (2021) https://doi.org/10.1117/12.2583939
Event: SPIE BiOS, 2021, Online Only

Abstract

Total Skin Electron Therapy (TSET) utilizes high-energy electrons to treat cancers on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high-energy electron beam and tissue. Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real-time using a time-gated intensified camera system. Each patient was monitored during TSET by in-vivo detectors (IVD) as well as Scintillators. Patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. A rigorous methodology for converting Cherenkov intensity to surface dose as products of correction factors, including camera vignette correction factor, incident radiation correction factor, and tissue optical properties correction factor. A comprehensive study has been carried out by inspecting various positions on the patients such as vertex, chest, perineum, shins, and foot relative to the umbilicus point (the prescription point).

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Timothy C. Zhu, Yihong Ong, Hongjing Sun, Weili Zhong, Tianshun Miao, Andreea Dimofte, Petr Bruza, Amit Maity, John P. Plastaras, Ima Paydar, Lei Dong, and Brian W. Pogue "Cherenkov imaging for total skin electron therapy: an evaluation of dose uniformity", Proc. SPIE 11628, Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation, 116280R (30 March 2021); https://doi.org/10.1117/12.2583939

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