Combining Raman spectroscopy and optical coherence tomography for correlated interpretation of morpho-molecular features on early stage bladder cancer

Fabian Placzek; Iwan Schie; Lara M. Wurster; Eliana C. Bautista; Simon Kretschmer; Florian Knorr; Çağlar Ataman; Gregers Gautier Hermann M.D.; Karin Mogensen; Thomas Hasselager; Hans Zappe; Jürgen Popp; Wolfgang Drexler; Rainer Andreas Leitgeb

doi:10.1117/12.2579561

5 March 2021 Combining Raman spectroscopy and optical coherence tomography for correlated interpretation of morpho-molecular features on early stage bladder cancer

Fabian Placzek, Iwan Schie, Lara M. Wurster, Eliana C. Bautista, Simon Kretschmer, Florian Knorr, Çağlar Ataman, Gregers Gautier Hermann M.D., Karin Mogensen, Thomas Hasselager, Hans Zappe, Jürgen Popp, Wolfgang Drexler, Rainer Andreas Leitgeb

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Proceedings Volume 11634, Multimodal Biomedical Imaging XVI; 116340S (2021) https://doi.org/10.1117/12.2579561
Event: SPIE BiOS, 2021, Online Only

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Abstract

Using the multimodal combination of optical coherence tomography (OCT) with Raman spectroscopy (RS) for obtaining morpho-molecular tissue characteristics of suspicious bladder cancer lesions for improved diagnostics and signal origin characterization. We present endoscopically acquired co-localized OCT-RS data on bladder cancer biopsies. The correlated OCT and RS data enables a new way of interpretation and understanding of signal origin for both imaging modalities. Histopathological findings serve as ground truth. Molecular signal contributions can be directly correlated to identified morphological features from the OCT and lead to a better understanding of underlying biological structures.

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Fabian Placzek, Iwan Schie, Lara M. Wurster, Eliana C. Bautista, Simon Kretschmer, Florian Knorr, Çağlar Ataman, Gregers Gautier Hermann M.D., Karin Mogensen, Thomas Hasselager, Hans Zappe, Jürgen Popp, Wolfgang Drexler, and Rainer Andreas Leitgeb "Combining Raman spectroscopy and optical coherence tomography for correlated interpretation of morpho-molecular features on early stage bladder cancer", Proc. SPIE 11634, Multimodal Biomedical Imaging XVI, 116340S (5 March 2021); https://doi.org/10.1117/12.2579561

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