Near-infrared spectroscopy-based system for assessment of cerebrovascular activity during stress

Stephanie Miller; Kunal Mitra

doi:10.1117/12.2590851

5 March 2021 Near-infrared spectroscopy-based system for assessment of cerebrovascular activity during stress

Stephanie Miller, Kunal Mitra

Proceedings Volume 11638, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II; 116380B (2021) https://doi.org/10.1117/12.2590851
Event: SPIE BiOS, 2021, Online Only

Abstract

Cerebral blood flow (CBF) dysregulation has been implicated in a wide variety of conditions. Cerebrovascular reactivity (CVR) to CO₂ may be a biomarker of CBF dysregulation. NIRS-measured regional cerebral tissue oxygen saturation (rSO₂) is a non-invasive measurement made with portable and relatively inexpensive devices. We previously reported that monitoring rSO2 can identify changes in cerebrovascular dynamics in response to hypercapnic breathing challenges. The present study builds on this work, employing rSO₂ to characterize changes in CBF correlates during hypercapnic breathing challenges, with a new focus on correlations with NIRS-measured vital signs. A custom breathing circuit was used to deliver a series of hypercapnic breathing challenges and recovery periods to healthy young adult subjects grouped into three exercise factors. Change in rSO₂ from intra- to pre-challenge (ΔrSO₂) correlated positively with change in heart rate (ΔHRhyp). Athletes showed higher ∆HRhyp than casual and non-exercisers. We previously established that athletes showed higher ΔrSO₂ responses to hypercapnic breathing challenges. While the relationships between ΔrSO₂ and ΔHRhyp and change in end tidal CO₂ (ΔPETCO₂) in response to hypercapnic breathing challenges appears to be in tact in the healthy young adults studied, and more pronounced in athletes, these relationships may not be preserved in cases of compromised CVR. Change in respiration rate correlated negatively with ΔPETCO₂. Establishing baseline values of rSO₂, PETCO₂, HR, and RR may be useful in identifying changes in an individual’s CVR. Combined monitoring of rSO₂, PETCO₂, HR, and RR presents a portable, inexpensive, noninvasive NIRS-based modality for detecting changes in cerebrovascular health.

Conference Presentation

Citation Download Citation

Stephanie Miller and Kunal Mitra "Near-infrared spectroscopy-based system for assessment of cerebrovascular activity during stress", Proc. SPIE 11638, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II, 116380B (5 March 2021); https://doi.org/10.1117/12.2590851

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