Frequency-domain diffuse optical spectroscopy with real-time data visualization for monitoring of breast neoplasms

Matthew B. Applegate; Robert Amelard; Carlos A. Gómez; Darren Roblyer

doi:10.1117/12.2578366

5 March 2021 Frequency-domain diffuse optical spectroscopy with real-time data visualization for monitoring of breast neoplasms

Matthew B. Applegate, Robert Amelard, Carlos A. Gómez, Darren Roblyer

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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 1163907 (2021) https://doi.org/10.1117/12.2578366
Event: SPIE BiOS, 2021, Online Only

Abstract

Diffuse optical methods have demonstrated significant potential to monitor breast cancer treatment response. Unfortunately, many diffuse optical tools involve lengthy acquisition, slow data processing, or both, limiting their clinical utility. Here, we present a new frequency domain diffuse optical device capable of providing real-time tissue oxygenation maps. This device is made possible through the integration of three enabling technologies: real-time 3D probe tracking, rapid translation of raw data to optical properties, and new high-speed acquisition electronics. We have demonstrated the ability of this instrument to identify inclusions in phantoms as well as to make proof-of-concept measurements in breast tissue.

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Matthew B. Applegate, Robert Amelard, Carlos A. Gómez, and Darren Roblyer "Frequency-domain diffuse optical spectroscopy with real-time data visualization for monitoring of breast neoplasms", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 1163907 (5 March 2021); https://doi.org/10.1117/12.2578366

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KEYWORDS

Diffuse optical spectroscopy

Breast

Data visualization

Optical properties

Optical simulations

Optical tracking

Tissue optics

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