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Diabetic foot is a well-known problem among patients suffering from peripheral arterial diseases (PAD). An optical sensor was built for a contactless measurement of the anatomical site, composing of a diode-laser and a high-speed camera. The laser illuminates the inspected tissue and the back reflected light forms time changing speckle patterns. We used second order autocorrelation function (ACF) decay time as merit for blood flow estimation. Clinical study with 15 subjects was conducted. An occlusion test was introduced to provoke a statistical parameter to distinguish between low perfused and a healthy foot.
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Mark Golberg, Ran Califa, Sagi Polani, Orit Goldstein, Aviram Zailer, Meir Niska, Zeev Zalevsky, "Assessment of tissue perfusion in the lower limbs using laser speckle analysis," Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410I (5 March 2021); https://doi.org/10.1117/12.2574630