In vivo evaluation of retinal neovascularization using chain-like cluster gold nanoparticle-enhanced multimodal photoacoustic microscopy and optical coherence tomography molecular imaging

Van Phuc Nguyen; Yanxiu Li; Wei Qian; Bing Liu; Jessica Henry; Wei Zhang; Xueding Wang; Yannis M. Paulus

doi:10.1117/12.2577660

5 March 2021 In vivo evaluation of retinal neovascularization using chain-like cluster gold nanoparticle-enhanced multimodal photoacoustic microscopy and optical coherence tomography molecular imaging

Van Phuc Nguyen, Yanxiu Li, Wei Qian, Bing Liu, Jessica Henry, Wei Zhang, Xueding Wang, Yannis M. Paulus

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Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116420H (2021) https://doi.org/10.1117/12.2577660
Event: SPIE BiOS, 2021, Online Only

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Abstract

Multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) have been developed for visualization of different retinal tissues such as retinal pigment endothelium (RPE), retinal and choroidal vessels, and retinal neovascularization (RNV) with promising results. However, one limitation of these studies is that it is hard to distinguish abnormal and healthy retinal vessels. To address such limitations, this study focused on the development of novel ultrapure chain-like cluster gold nanoparticles (CGNPs) to boost the PAM and OCT image contrast for enhanced visualization of RNV. CGNPs have a redshift plasmonic absorption peak at 650 nm where blood vessels generate a very low intrinsic photoacoustic signal, resulting in enhanced signal-to-noise ratio, and thus allowing for distinguishing RNV. Toxicity of CGNPs was tested on three different cells: bovine retinal endothelial cells (BRECs), HeLa cells, and brain endothelial cells (b.End3). The ability of CGNPs for contrast

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Van Phuc Nguyen, Yanxiu Li, Wei Qian, Bing Liu, Jessica Henry, Wei Zhang, Xueding Wang, and Yannis M. Paulus "In vivo evaluation of retinal neovascularization using chain-like cluster gold nanoparticle-enhanced multimodal photoacoustic microscopy and optical coherence tomography molecular imaging", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420H (5 March 2021); https://doi.org/10.1117/12.2577660

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