Photoacoustic neuronal stimulation by nanotransducers operating at NIR II window

Yimin Huang; Ying Jiang; Jiayingzi Wu; Jianguo Mei; Ji-Xin Cheng; Chen Yang

doi:10.1117/12.2577312

5 March 2021 Photoacoustic neuronal stimulation by nanotransducers operating at NIR II window

Yimin Huang, Ying Jiang, Jiayingzi Wu, Jianguo Mei, Ji-Xin Cheng, Chen Yang

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422Q (2021) https://doi.org/10.1117/12.2577312
Event: SPIE BiOS, 2021, Online Only

Abstract

Toward non-genetic non-invasive neural modulation with a submillimeter precision, we report the development and application of photoacoustic nanotransducers (PAN) to neural stimulation in cultured primary neurons and in live brain. Our PAN, based on synthesized semiconducting polymer nanoparticles, efficiently generate localized ultrasound by a photoacoustic process upon absorption of nanosecond pulsed light in the NIR-II window. We showed that PAN binding on the neuron membrane through non-specific interaction and specific targeting of mechanosensitive ion channels both successfully activate primary neurons in culture. We also demonstrated in live mouse brain motor cortex activation and invoked subsequent motor responses through PAN.

Conference Presentation

Citation Download Citation

Yimin Huang, Ying Jiang, Jiayingzi Wu, Jianguo Mei, Ji-Xin Cheng, and Chen Yang "Photoacoustic neuronal stimulation by nanotransducers operating at NIR II window", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422Q (5 March 2021); https://doi.org/10.1117/12.2577312

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