Surface enhanced Raman scattering (SERS) nanoparticles for rapid chemical analysis of tumor-associated extracellular vesicles (EVs)

Randy Carney; Tatu Rojalin; Hanna Koster; Hannah J. O'Toole; Sebastian Wachsmann-Hogiu

doi:10.1117/12.2577297

5 March 2021 Surface enhanced Raman scattering (SERS) nanoparticles for rapid chemical analysis of tumor-associated extracellular vesicles (EVs)

Randy Carney, Tatu Rojalin, Hanna Koster, Hannah J. O'Toole, Sebastian Wachsmann-Hogiu

Author Affiliations +

Proceedings Volume 11659, Colloidal Nanoparticles for Biomedical Applications XVI; 116590H (2021) https://doi.org/10.1117/12.2577297
Event: SPIE BiOS, 2021, Online Only

Abstract

Sensitive and specific detection of biomaterials packaged in exosomes and related extracellular vesicles (EVs) has the potential to revolutionize cancer diagnosis and monitoring. Yet current methods cannot readily distinguish tumor-associated EVs. Surface-enhanced Raman spectroscopy (SERS) represents a promising tool to address current limitations, but are challenging to implement in whole biofluids. Here we outline a simple SERS assay combining nanoparticles with biofluids purified to various extent. We measure variation between clinical samples of head and neck cancer and demonstrate that there is a trade-off between useful molecular information from purified EVs versus the time, cost, and difficulty of isolation procedures.

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Citation Download Citation

Randy Carney, Tatu Rojalin, Hanna Koster, Hannah J. O'Toole, and Sebastian Wachsmann-Hogiu "Surface enhanced Raman scattering (SERS) nanoparticles for rapid chemical analysis of tumor-associated extracellular vesicles (EVs)", Proc. SPIE 11659, Colloidal Nanoparticles for Biomedical Applications XVI, 116590H (5 March 2021); https://doi.org/10.1117/12.2577297

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