Optofluidic fiber- based nanoparticle tracking analysis: tool to characterize diffusing nanoscale specimen such as SARS-CoV-2

Markus A. Schmidt; Torsten Wieduwilt; Malte Plidschun; Mona Nissen; Shiqi Jiang; Ronny Förster

doi:10.1117/12.2597806

18 April 2021 Optofluidic fiber- based nanoparticle tracking analysis: tool to characterize diffusing nanoscale specimen such as SARS-CoV-2

Markus A. Schmidt, Torsten Wieduwilt, Malte Plidschun, Mona Nissen, Shiqi Jiang, Ronny Förster

Author Affiliations +

Proceedings Volume 11773, Micro-structured and Specialty Optical Fibres VII; 1177309 (2021) https://doi.org/10.1117/12.2597806
Event: SPIE Optics + Optoelectronics, 2021, Online Only

Abstract

High-speed tracking of nano-objects is a gateway to understanding biological processes at the nanoscale. Here we will present our results on tracking single or ensembles of nano-objects inside optofluidic fibers via elastic light scattering. The nano-objects diffuse inside a channel of a microstructured fiber and the light scattered by the nano-object is detected transversely via a microscope. We will present the fundamentals of this approach and focus on selected results including retrieval of the full 3D trajectory of a diffusing nano-sphere, the simultaneous detection of hundreds of nano-objects in hollow core anti-resonant fibers and first results on inactivated SARS-CoV-2.

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Citation Download Citation

Markus A. Schmidt, Torsten Wieduwilt, Malte Plidschun, Mona Nissen, Shiqi Jiang, and Ronny Förster "Optofluidic fiber- based nanoparticle tracking analysis: tool to characterize diffusing nanoscale specimen such as SARS-CoV-2", Proc. SPIE 11773, Micro-structured and Specialty Optical Fibres VII, 1177309 (18 April 2021); https://doi.org/10.1117/12.2597806

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