Optical manipulation and detection of living cells and nanoparticles using optical fibers

Yuchao Li; Yao Zhang; Baojun Li

doi:10.1117/12.2593387

20 June 2021 Optical manipulation and detection of living cells and nanoparticles using optical fibers

Yuchao Li, Yao Zhang, Baojun Li

Author Affiliations +

Proceedings Volume 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V; 117860S (2021) https://doi.org/10.1117/12.2593387
Event: SPIE Optical Metrology, 2021, Online Only

Abstract

With observation of small objects, a precisely manipulation is also highly desirable, especially for a three-dimensional manipulation of nanoparticles or biomolecules with a size of less than 100 nm. Although optical tweezers have become powerful tools to manipulate microparticles and cells, they have limits when extended to the nanoscale because of the fundamental diffraction limit of light. The emergence of near-field methods, such as plasmonic tweezers and photonic crystal resonators, have enabled surpassing of the diffraction limit. However, these methods are usually used for two-dimensional manipulation and may lead to local heating effects that will damage the biological specimens. Therefore, we propose a near-field technique that uses a photonic nanojet to perform the three-dimensional optical manipulation of sub-100-nm objects. With the photonic nanojet generated by a dielectric microlens bound to an optical fiber probe, three-dimensional manipulations were achieved for fluorescent nanoparticles as well as for plasmid DNA molecules. Backscattering and fluorescent signals from the trapped targets were detected in real time with a strong enhancement. The demonstrated approach provides a potentially powerful tool for nanostructure assembly, biosensing and single-biomolecule studies.

Conference Presentation

Citation Download Citation

Yuchao Li, Yao Zhang, and Baojun Li "Optical manipulation and detection of living cells and nanoparticles using optical fibers", Proc. SPIE 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, 117860S (20 June 2021); https://doi.org/10.1117/12.2593387

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Nanoparticles

Optical fibers

Optical manipulation

3D acquisition

Diffraction

Near field

Photonic nanostructures

Show All Keywords

Keywords/Phrases

Search In:

Publication Years