Study of spatial distribution of upconversion nanoparticles in sections of rat organs and tumors by the luminescent method

Irina Yu. Yanina; Artem M. Mylnikov; Nikita A. Navolokin; Ivan V. Fedosov; Vyacheslav I. Kochubey

doi:10.1117/12.2615415

9 December 2021 Study of spatial distribution of upconversion nanoparticles in sections of rat organs and tumors by the luminescent method

Irina Yu. Yanina, Artem M. Mylnikov, Nikita A. Navolokin, Ivan V. Fedosov, Vyacheslav I. Kochubey

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Proceedings Volume 11920, Diffuse Optical Spectroscopy and Imaging VIII; 119201R (2021) https://doi.org/10.1117/12.2615415
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

Visualization of the spatial distribution of nanoparticles in organs and tumors is a rapidly developing field in terms of diagnostics and therapy of oncological diseases. The method of imaging up-conversion nanoparticles in tissues and organs using a scanning system has become widespread. In this case, the exciting radiation is focused on the surface of the object, the luminescence is collected by a wide-aperture optical system and is recorded by a photodetector. The aim of this study was to register the spatial distribution of upconversion nanoparticles in sections of organs and tumors of laboratory animals in health and disease (liver cancer) using a fluorescent microscope. It was shown that upconversion nanoparticles accumulate mainly in the spleen, which is confirmed by the data of histopathological analysis. With a three-fold intravenous injection of particles, their maximum accumulation in the tumor tissue occurs. In general, the particles accumulated in the tumor and did not damage organs, tissues, or erythrocytes.

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Irina Yu. Yanina, Artem M. Mylnikov, Nikita A. Navolokin, Ivan V. Fedosov, and Vyacheslav I. Kochubey "Study of spatial distribution of upconversion nanoparticles in sections of rat organs and tumors by the luminescent method", Proc. SPIE 11920, Diffuse Optical Spectroscopy and Imaging VIII, 119201R (9 December 2021); https://doi.org/10.1117/12.2615415

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KEYWORDS

Tumors

Nanoparticles

Tissues

Particles

Upconversion

Luminescence

Erbium

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