Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)

Robert J. Zawadzki; Pengfei Zhang; Ewelina Pijewska; Denise Valente; Ratheesh K. Meleppat; Kari V. Vienola; Sarah J. Karlen; M. Szkulmowski; John S. Werner; Edward N. Pugh; Ravi S. Jonnal

doi:10.1117/12.2616045

9 December 2021 Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)

Robert J. Zawadzki, Pengfei Zhang, Ewelina Pijewska, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, M. Szkulmowski, John S. Werner, Edward N. Pugh, Ravi S. Jonnal

Author Affiliations +

Proceedings Volume 11924, Optical Coherence Imaging Techniques and Imaging in Scattering Media IV; 119240M (2021) https://doi.org/10.1117/12.2616045
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology, because it should provide more sensitive tools for ocular diseases diagnostic that would go beyond current gold standard of simple evaluation of the static retinal morphology. In this presentation we will review our recent progress in measurements and interpretation of OCT-based optoretinograms (ORG) i.e., the paradigm of using NIR OCT to measure in vivo bleaching-induced changes in retinal morphology (transient changes in volume of individual neurons, or thickness of retinal layers). Specifically, comparison between different instrumentations used to acquire ORGs and between results acquired using clinical (human) and experimental (animal) systems will be presented. Additionally, intensity-based and phase-based ORG extraction framework will be presented. Finally, we will discuss our findings in the context of current understanding of measured process, being a result osmotically driven water movements between the photoreceptors, and other retinal neurons and its surroundings.

Citation Download Citation

Robert J. Zawadzki, Pengfei Zhang, Ewelina Pijewska, Denise Valente, Ratheesh K. Meleppat, Kari V. Vienola, Sarah J. Karlen, M. Szkulmowski, John S. Werner, Edward N. Pugh, and Ravi S. Jonnal "Progress in measurements and interpretation of light-evoked retinal function using OCT based optoretinography (ORG)", Proc. SPIE 11924, Optical Coherence Imaging Techniques and Imaging in Scattering Media IV, 119240M (9 December 2021); https://doi.org/10.1117/12.2616045

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available