Reactive oxygen species explicit dosimetry (ROSED) for fractionated photofrin-mediated photodynamic therapy (PDT)

Hongjing Sun; Yi Hong Ong; Timothy C. Zhu

doi:10.1117/12.2609969

4 March 2022 Reactive oxygen species explicit dosimetry (ROSED) for fractionated photofrin-mediated photodynamic therapy (PDT)

Hongjing Sun, Yi Hong Ong, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; 1194007 (2022) https://doi.org/10.1117/12.2609969
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Photodynamic therapy (PDT) is an established modality for cancer treatment and reactive oxygen species explicit dosimetry (ROSED), based on direct measurements of in-vivo light fluence (rate), in-vivo photofrin concentration, and tissue oxygenation concentration, has been proved to be an effective dosimetric quantity which can be used to predict PDT outcome. In this study, ROSED was performed for photofrin-mediated PDT for mice bearing radiation-induced fibrosacorma (RIF) tumor. PDT treatments were performed using single or fractionated illumination to a same total fluence of 135 Jcm^-2. The effects of light fractionation on the total reacted [ROS]_rx and treatment outcomes were evaluated.

Conference Presentation

Citation Download Citation

Hongjing Sun, Yi Hong Ong, and Timothy C. Zhu "Reactive oxygen species explicit dosimetry (ROSED) for fractionated photofrin-mediated photodynamic therapy (PDT)", Proc. SPIE 11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, 1194007 (4 March 2022); https://doi.org/10.1117/12.2609969

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