Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open orthopedic surgery

Yue Tang; Jessica M. Sin; I. Leah Gitajn; Xu Cao; Xinyue Han; Jonathan T. Elliott; Xiaohan Yu; Melanie L. Christian; Logan Bateman; Theresa Chockbengboun; Eric R. Henderson; Brian W. Pogue; Shudong Jiang

doi:10.1117/12.2608382

4 March 2022 Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open orthopedic surgery

Yue Tang, Jessica M. Sin, I. Leah Gitajn, Xu Cao, Xinyue Han, Jonathan T. Elliott, Xiaohan Yu, Melanie L. Christian, Logan Bateman, Theresa Chockbengboun, Eric R. Henderson, Brian W. Pogue, Shudong Jiang

Author Affiliations +

Proceedings Volume 11943, Molecular-Guided Surgery: Molecules, Devices, and Applications VIII; 119430C (2022) https://doi.org/10.1117/12.2608382
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

ICG-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) and intraoperative DCE- magnetic resonance imaging (MRI) have been carried out nearly simultaneously in three lower extremity bone infection cases to investigate the relationship between these two imaging modalities for assessing bone blood perfusion during open orthopedic surgeries. Time-intensity curves in the corresponding regions of interest of two modalities were derived for comparison. The results demonstrated that ICG-based DCE-FI has higher sensitivity to perfusion changes while DCE-MRI provides superior and supplemental depth-related perfusion information. Research applying the depth-related perfusion information derived from MRI to improve the overall analytic modeling of intraoperative DCE-FI is ongoing.

Conference Presentation

Citation Download Citation

Yue Tang, Jessica M. Sin, I. Leah Gitajn, Xu Cao, Xinyue Han, Jonathan T. Elliott, Xiaohan Yu, Melanie L. Christian, Logan Bateman, Theresa Chockbengboun, Eric R. Henderson, Brian W. Pogue, and Shudong Jiang "Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open orthopedic surgery", Proc. SPIE 11943, Molecular-Guided Surgery: Molecules, Devices, and Applications VIII, 119430C (4 March 2022); https://doi.org/10.1117/12.2608382

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available