Methylene blue uptake and biological elimination preliminary study in Drosophila for regulation of long-term photodynamics

Jace A. Willis; Vladislav V. Yakovlev

doi:10.1117/12.2610309

2 March 2022 Methylene blue uptake and biological elimination preliminary study in Drosophila for regulation of long-term photodynamics

Jace A. Willis, Vladislav V. Yakovlev

Author Affiliations +

Proceedings Volume 11959, Dynamics and Fluctuations in Biomedical Photonics XIX; 1195904 (2022) https://doi.org/10.1117/12.2610309
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Photosensitizer uptake and elimination are studied in the animal model D. melanogaster with the purpose of developing tools for highly regulated photodynamic therapy (PDT) as a model of accelerated aging and neurodegenerative disorders. The photosensitizer (PS) methylene blue (MB) is given in a concentration of 1 mM by mixing with growth media for fly consumption. Internal MB increases for eight hours following exposure to MB media. At this time, the mean trends of these early results show adequate uptake rate and maximum internal MB for PDT utility in the D. melanogaster model and potential for further applications in disease modelling.

Conference Presentation

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Jace A. Willis and Vladislav V. Yakovlev "Methylene blue uptake and biological elimination preliminary study in Drosophila for regulation of long-term photodynamics", Proc. SPIE 11959, Dynamics and Fluctuations in Biomedical Photonics XIX, 1195904 (2 March 2022); https://doi.org/10.1117/12.2610309

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