Assessment of microvascular in critically ill patients based on speckle variance OCT: animal study

Zhiwei Hu; Dezi Li; Jialing Zhang; Haiyu Chen; Zhongxin Liu; Liangwei Dong; Xibing Liu; Zhifang Li

doi:10.1117/12.2604841

13 December 2021 Assessment of microvascular in critically ill patients based on speckle variance OCT: animal study

Zhiwei Hu, Dezi Li, Jialing Zhang, Haiyu Chen, Zhongxin Liu, Liangwei Dong, Xibing Liu, Zhifang Li

Proceedings Volume 12072, 10th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Micro- and Nano-Optics, Catenary Optics, and Subwavelength Electromagnetics; 1207204 (2021) https://doi.org/10.1117/12.2604841
Event: Tenth International Symposium on Advanced Optical Manufacturing and Testing Technologies (AOMATT 2021), 2021, Chengdu, China

Abstract

In this study, surgical operation for the myocardial ischemia of rat was used to simulate the model of critically ill patients. Speckle variance optical coherence tomography was applied to study the effects of myocardial ischemia on blood microcirculation. The main method is to simulate the severe condition through the heart ligation operation in rats, and then the OCT system is used to image the ear of rats. First of all, the variance operation is performed on the same position of the structure map through speckle variance algorithm, so as to obtain the blood flow intensity information. Finally, the vascular morphological structure can be roughly seen through the basic vascular enhancement algorithm. A comparison of vascular images before and after heart ligation surgery revealed that surgery had a significant effect on the circulation of microvessels, and many microvessels were lost intermittently after surgery. Accurate in vivo study model is very important to obtain OCT images and accurate analysis, and it is of great value to promote the development of microangiography4 and its clinical application.

Citation Download Citation

Zhiwei Hu, Dezi Li, Jialing Zhang, Haiyu Chen, Zhongxin Liu, Liangwei Dong, Xibing Liu, and Zhifang Li "Assessment of microvascular in critically ill patients based on speckle variance OCT: animal study", Proc. SPIE 12072, 10th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Micro- and Nano-Optics, Catenary Optics, and Subwavelength Electromagnetics, 1207204 (13 December 2021); https://doi.org/10.1117/12.2604841

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KEYWORDS

Optical coherence tomography

Speckle

Image processing

Tissues

Angiography

Ear

3D image reconstruction

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