Chemical visualization with optically super-resolved infrared imaging micro-spectroscopy

T. J. Huffman; Robert Furstenberg; Christopher A. Kendziora; R. A. McGil

doi:10.1117/12.2619074

31 May 2022 Chemical visualization with optically super-resolved infrared imaging micro-spectroscopy

T. J. Huffman, Robert Furstenberg, Christopher A. Kendziora, R. A. McGil

Proceedings Volume 12098, Dimensional Optical Metrology and Inspection for Practical Applications XI; 120980E (2022) https://doi.org/10.1117/12.2619074
Event: SPIE Defense + Commercial Sensing, 2022, Orlando, Florida, United States

Abstract

Optically Super-resolved InfraRed Imaging micro-Spectroscopy (OSIRIS) is a novel technique to break the tension between spectroscopy (wavelength) and microscopy (spatial resolution) inherent in the diffraction limit. In OSIRIS, modulated long wavelength “pump” light is directed onto the sample, while a short wavelength “probe” beam senses the resultant modulation in local temperature. Spectra are collected by varying the wavelength of the modulated light. We describe a method of spectral de-mixing based on a Bayesian approach to identify the statistically distinct chemical fingerprints (spectra) in the hyperspectral image. This result also reveals the amount of each material at each point in space, which can then be used to digitally stain the image to present an easily interpretable image to the end user.

Conference Presentation

Citation Download Citation

T. J. Huffman, Robert Furstenberg, Christopher A. Kendziora, and R. A. McGil "Chemical visualization with optically super-resolved infrared imaging micro-spectroscopy", Proc. SPIE 12098, Dimensional Optical Metrology and Inspection for Practical Applications XI, 120980E (31 May 2022); https://doi.org/10.1117/12.2619074

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