X-ray phase-contrast imaging by grating interferometry has in the past decades been established both at synchrotron radiation sources and at conventional x-ray tubes. Due to the sensitivity to x-ray phase shifting, contrast in soft tissue has been improved significantly and the possibilities to do virtual histology of tissue biopsies are being pioneered. Constraints in the design of a grating interferometer are dominated by the phase-shifting structures of the gratings. Typically, binary gratings are used, with alternating regions of shift and no shift. However, other structures are also possible, leading to different patterns of intensity modulations. Here we simulate the possibility of using multiple binary structures in the phase grating, to utilize Moiré effects and avoid the use of attenuating grating structures. In particular the parameters for grating-based phase-contrast imaging using a single optical element are discussed, with focus on laboratory-based x-ray imaging using microfocus sources.
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