Differences in the spatial distribution of tumor cells at breast cancer borders based on multiphoton imaging

Shichao Zhang; Ying Feng; Jikui Miao; Liqin Zheng; Xiahui Han; Lianhuang Li; Deyong Kang; Jianxin Chen

doi:10.1117/12.2644074

19 December 2022 Differences in the spatial distribution of tumor cells at breast cancer borders based on multiphoton imaging

Shichao Zhang, Ying Feng, Jikui Miao, Liqin Zheng, Xiahui Han, Lianhuang Li, Deyong Kang, Jianxin Chen

Author Affiliations +

Proceedings Volume 12320, Optics in Health Care and Biomedical Optics XII; 123200J (2022) https://doi.org/10.1117/12.2644074
Event: SPIE/COS Photonics Asia, 2022, Online Only

Abstract

Tumor cell invasion and metastasis is closely related to various components in tumor microenvironment, and the spatial distribution of tumor cells may be linked to the tumor progression. The directionally distributed collagen fibers would lead to one-way migration of tumor cells, and misarranged collagen fibers allow tumor cells to multi-directional migration in tumor boundary, and therefore tumor cells present in different spatial distributions in the microenvironment. In this study, the open source convolutional neural network Hover-Net was used for segmentation and classification. After accurately segmenting tumor cells, spatial features were extracted. Our results indicated that there were significant differences in the spatial distribution of tumor cells in the two modes. These were further demonstrated to be potential different prognostic patterns.

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Shichao Zhang, Ying Feng, Jikui Miao, Liqin Zheng, Xiahui Han, Lianhuang Li, Deyong Kang, and Jianxin Chen "Differences in the spatial distribution of tumor cells at breast cancer borders based on multiphoton imaging", Proc. SPIE 12320, Optics in Health Care and Biomedical Optics XII, 123200J (19 December 2022); https://doi.org/10.1117/12.2644074

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