Label-free protein quantitation using liquid crystal-enhanced optofluidic biosensor

Ziyihui Wang; Tianhua Xu; Haonan Wang; Yize Liu; Kun Liu; Junfeng Jiang; Yu-Cheng Chen; Tiegen Liu

doi:10.1117/12.2638371

19 December 2022 Label-free protein quantitation using liquid crystal-enhanced optofluidic biosensor

Ziyihui Wang, Tianhua Xu, Haonan Wang, Yize Liu, Kun Liu, Junfeng Jiang, Yu-Cheng Chen, Tiegen Liu

Proceedings Volume 12321, Advanced Sensor Systems and Applications XII; 123210Q (2022) https://doi.org/10.1117/12.2638371
Event: SPIE/COS Photonics Asia, 2022, Online Only

Conference Poster

Abstract

Protein detection plays an important role in the medical research. Liquid crystals (LCs), as a class of sensitive materials, exhibit a promising ability in the biosensing field. Herein, we exploited an ultrasensitive biosensor for protein detection, employing the whispering-gallery-mode (WGM) from the LC-amplified optofluidic micro-resonator. The biomolecules can trigger both light-matter interactions and the orientation transitions of LC molecules. The WGM spectral wavelength shift was recorded as the sensing indicator, and a detection limit of 15 fM for bovine serum albumin (BSA) was achieved. Our LC-amplified optofluidic biosensor provides a new solution for the ultrasensitive, real-time, and stable biological detection.

Citation Download Citation

Ziyihui Wang, Tianhua Xu, Haonan Wang, Yize Liu, Kun Liu, Junfeng Jiang, Yu-Cheng Chen, and Tiegen Liu "Label-free protein quantitation using liquid crystal-enhanced optofluidic biosensor", Proc. SPIE 12321, Advanced Sensor Systems and Applications XII, 123210Q (19 December 2022); https://doi.org/10.1117/12.2638371

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