A Monte Carlo simulation for moving light source in intracavity PDT

Evgueni Parilov; Karl Beeson; Mary Potasek; Timothy Zhu; Hongjing Sun; Dennis Sourvanos

doi:10.1117/12.2649538

14 March 2023 A Monte Carlo simulation for moving light source in intracavity PDT

Evgueni Parilov, Karl Beeson, Mary Potasek, Timothy Zhu, Hongjing Sun, Dennis Sourvanos

Proceedings Volume 12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; 1235903 (2023) https://doi.org/10.1117/12.2649538
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We developed a simulation method for modeling the light fluence delivery in intracavity Photodynamic Therapy (icav-PDT) for pleural lung cancer using a moving light source. Due to the large surface area of the pleural lung cavity, the light source needs to be moved to deliver a uniform dose around the entire cavity. While multiple fixed detectors are used for dosimetry at a few locations, an accurate simulation of light fluence and fluence rate is still needed for the rest of the cavity. We extended an existing Monte Carlo (MC) based light propagation solver to support moving light sources by densely sampling the continuous light source trajectory and assigning the proper number of photon packages launched along the way. The performance of Simphotek GPU CUDA-based implementation of the method – PEDSy-MC – has been demonstrated on a life-size lung-shaped phantom, custom printed for testing icav-PDT navigation system at the Perlman School of Medicine (PSM) – calculations completed under a minute (for some cases) and within minutes have been achieved. We demonstrate results within a 5% error of the analytic solution for multiple detectors in the phantom. PEDSy-MC is accompanied by a dose-cavity visualization tool that allows real-time inspection of dose values of the treated cavity in 2D and 3D, which will be expanded to ongoing clinical trials at PSM. PSM has developed a technology to measure 8-detectors in a pleural cavity phantom using Photofrin-mediated PDT that has been used during validation.

Conference Presentation

Citation Download Citation

Evgueni Parilov, Karl Beeson, Mary Potasek, Timothy Zhu, Hongjing Sun, and Dennis Sourvanos "A Monte Carlo simulation for moving light source in intracavity PDT", Proc. SPIE 12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, 1235903 (14 March 2023); https://doi.org/10.1117/12.2649538

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