Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

Kenneth M. Tichauer; Cody Rounds; Veronica C. Torres; Chengyue Li; Hang Nguyen; Thom S. Nijboer; Floris J. Voskuil; Jovan G. Brankov; Max J. H. Witjes

doi:10.1117/12.2654231

14 March 2023 Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

Kenneth M. Tichauer, Cody Rounds, Veronica C. Torres, Chengyue Li, Hang Nguyen, Thom S. Nijboer, Floris J. Voskuil, Jovan G. Brankov, Max J. H. Witjes

Author Affiliations +

Proceedings Volume 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; 123610C (2023) https://doi.org/10.1117/12.2654231
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.

Conference Presentation

Citation Download Citation

Kenneth M. Tichauer, Cody Rounds, Veronica C. Torres, Chengyue Li, Hang Nguyen, Thom S. Nijboer, Floris J. Voskuil, Jovan G. Brankov, and Max J. H. Witjes "Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures", Proc. SPIE 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, 123610C (14 March 2023); https://doi.org/10.1117/12.2654231

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available