Drug delivery and optical neuromodulation using a structured polymer optical fiber with ultra-high NA

Kunyang Sui; Marcello Meneghetti; Jaspreet Kaur; R. J. F. Sørensen; Rune W. Berg; Christos Markos

doi:10.1117/12.2647117

14 March 2023 Drug delivery and optical neuromodulation using a structured polymer optical fiber with ultra-high NA

Kunyang Sui, Marcello Meneghetti, Jaspreet Kaur, R. J. F. Sørensen, Rune W. Berg, Christos Markos

Proceedings Volume 12366, Optogenetics and Optical Manipulation 2023; 1236604 (2023) https://doi.org/10.1117/12.2647117
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Implantable optical fibers have been widely used for optical neuromodulation in deep brain regions. Polymer fiber-based neural devices have natural advantages over silica fibers since their high flexibility would lead to a less inflammatory response in chronic in vivo experiments. Using three kinds of polymer materials: polycarbonate (PC), polysulfone (PSU), and fluorinated ethylene propylene (FEP), we present multifunctional soft polymer fiber (POF)-based brain implants with an Ultra-High Numerical Aperture (UHNA) and integrated Microfluidic Channels (MCs) for wide illumination and drug delivery, respectively. The flexibility of the proposed fiber devices has been found to be 100-fold reduced compared to their commercially available counterparts. Biofluids delivery can be controllably achieved over a wide range of injection rates spanning from 10 nL/min to 1000 nL/min by the structured MCs in the fiber cladding. The illumination area of the UHNA POFs in brain phantom has been increased significantly compared with the commercially available silica fibers. A fluorescent light recording experiment has been conducted to demonstrate the proposed UHNA POFs can be used as optical waveguides in fiber photometry. The limited illumination angle of the optical fiber imposed by current technology has been enlarged by the proposed UHNA POFs and we anticipate our work to pave the way toward more efficient multifunctional neural probes for neuroscience.

Conference Presentation

Citation Download Citation

Kunyang Sui, Marcello Meneghetti, Jaspreet Kaur, R. J. F. Sørensen, Rune W. Berg, and Christos Markos "Drug delivery and optical neuromodulation using a structured polymer optical fiber with ultra-high NA", Proc. SPIE 12366, Optogenetics and Optical Manipulation 2023, 1236604 (14 March 2023); https://doi.org/10.1117/12.2647117

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available