Infrared neural stimulation and electrophysiology in a soft fiber-based neural interface

Marcello Meneghetti; Kunyang Sui; Jaspreet Kaur; Jakob F. Sørensen; Rune W. Berg; Christos Markos

doi:10.1117/12.2646177

14 March 2023 Infrared neural stimulation and electrophysiology in a soft fiber-based neural interface

Marcello Meneghetti, Kunyang Sui, Jaspreet Kaur, Jakob F. Sørensen, Rune W. Berg, Christos Markos

Proceedings Volume 12366, Optogenetics and Optical Manipulation 2023; 1236605 (2023) https://doi.org/10.1117/12.2646177
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Infrared neurostimulation has emerged in recent years as a promising technique for controlling neuronal activity without genetic manipulation. Having high absorption of the employed wavelengths as its fundamental mechanism, it requires implantable platforms to deliver light in brain regions deeper than the first cortical layers. Due to the spatial confinement of the stimulation, electrodes integrated in close proximity to the illumination spot are desirable to verify the effects of the stimulation by extracellular electrophysiology. Here we developed and validated in vivo a multifunctional neural interface based on a soft, biocompatible polymer optical fiber that allows simultaneous infrared neurostimulation and electrophysiology.

Conference Presentation

Citation Download Citation

Marcello Meneghetti, Kunyang Sui, Jaspreet Kaur, Jakob F. Sørensen, Rune W. Berg, and Christos Markos "Infrared neural stimulation and electrophysiology in a soft fiber-based neural interface", Proc. SPIE 12366, Optogenetics and Optical Manipulation 2023, 1236605 (14 March 2023); https://doi.org/10.1117/12.2646177

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