Non-invasive continuous hypoxia assessment in intra-partum fetus through long wavelength near infrared spectroscopy

Shree Krishnamoorthy; Urbashi Basu; Kiangwei Kho; Rekha Gautam; Francesca Di Croce; Walter Messina; Cleitus Antony; Paul Townsend; Fergus P. McCarthy; Stefan Andersson-Engels; Ray Burke

doi:10.1117/12.2648375

8 March 2023 Non-invasive continuous hypoxia assessment in intra-partum fetus through long wavelength near infrared spectroscopy

Shree Krishnamoorthy, Urbashi Basu, Kiangwei Kho, Rekha Gautam, Francesca Di Croce, Walter Messina, Cleitus Antony, Paul Townsend, Fergus P. McCarthy, Stefan Andersson-Engels, Ray Burke

Author Affiliations +

Proceedings Volume 12428, Photonic Instrumentation Engineering X; 124280M (2023) https://doi.org/10.1117/12.2648375
Event: SPIE OPTO, 2023, San Francisco, California, United States

Abstract

Intra-partum hypoxia is the principal cause of death for every 2 in 10000 infants. Monitoring hypoxia during child-birth will not only prevent infant mortality, but also help prevent cerebral palsy in 10-20% of the surviving babies. Current monitoring techniques either use an indirect biomarker (heart-rate in cardiotocograph) or measure downstream biomarkers intermittently and invasively (fetal blood sampling). For complete fetal wellbeing monitoring, a continuous non-invasive assessment of multiple biomarkers is needed during birth. To address this gap we are developing a noninvasive, continuous sensor based on long wavelength near infrared (LW-NIR) spectroscopic technique for the detection of fetal hypoxia through multiple biomarkers. For specific hypoxia assessment we have identified key optical spectroscopy compatible biomarkers from a list of various biomarkers effected in the physiological processes leading to the development of hypoxia. The key biomarkers identified are – cytochrome-C oxidase, oxygenated and deoxygenated hemoglobin, lactate, pyruvate and pH in the connective tissue in presence of other interferences such as lipids, proteins and other sugars. To translate these biomarkers into a viable diffuse-reflectance probe we assessed the light-tissue interaction in the low-scattering, water-absorption dominated LW-NIR window of 1350-2500 nm using Monte Carlo photon migration model and experimentally verified the penetration depth achievable in fetal tissue phantom to ~0.5 mm, only targeting the capillary bed.

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Citation Download Citation

Shree Krishnamoorthy, Urbashi Basu, Kiangwei Kho, Rekha Gautam, Francesca Di Croce, Walter Messina, Cleitus Antony, Paul Townsend, Fergus P. McCarthy, Stefan Andersson-Engels, and Ray Burke "Non-invasive continuous hypoxia assessment in intra-partum fetus through long wavelength near infrared spectroscopy", Proc. SPIE 12428, Photonic Instrumentation Engineering X, 124280M (8 March 2023); https://doi.org/10.1117/12.2648375

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