Near-infrared brain imaging based on nanomaterials

Yiqun Li

doi:10.1117/12.2669410

24 March 2023 Near-infrared brain imaging based on nanomaterials

Yiqun Li

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126111A (2023) https://doi.org/10.1117/12.2669410
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Brain is the most complex tissue in our bodies. A non-invasive way to capture brain images has important clinical meaning. Near infrared (NIR) imaging based on NIR fluorophores is an innovative way because of its high tissue penetration. Blood-brain barrier (BBB) is the blood vessel that vascularizes the central nervous system, which limits the transportation between blood and neutral tissues. Different strategies have been used to make nanoprobes across BBB. Nanomaterials are the emerging material of NIR imaging probes because of its good and tunable optical properties, biocompatibility, and surface modifiability. Proper functionalization makes nanoprobes have ability to target single molecule in brain. It facilitates the imaging of many brain diseases, such as, brain tumor, traumatic brain injury, and Alzheimer’s disease. In this review, different nanomaterials as candidates of NIR fluorescence imaging probe material will be discussed, including single-wall carbon nanotubes (SWCNTs), gold nanoparticles (AuNPs), quantum dots, aggregation-induced emission (AIE) dots, metal-organic frameworks (MOFs), covalent-organic frameworks (COFs). Different advantages, properties, and images will be discussed.

Citation Download Citation

Yiqun Li "Near-infrared brain imaging based on nanomaterials", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126111A (24 March 2023); https://doi.org/10.1117/12.2669410

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KEYWORDS

Near infrared

Brain

Nanoprobes

Nanomaterials

Fluorescence

Brain imaging

Blood brain barrier

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