The possibility of MSLN, ANTXR1, and ROR1 to become the target of CAR T cell therapy for treating TNBC and lung cancer

Jianshi Zhu

doi:10.1117/12.2669662

24 March 2023 The possibility of MSLN, ANTXR1, and ROR1 to become the target of CAR T cell therapy for treating TNBC and lung cancer

Jianshi Zhu

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126113G (2023) https://doi.org/10.1117/12.2669662
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Triple-negative breast cancer is a kind of subtype of the breast cancer that hard to be treated due to the mutation help the cancer escape most clinical treatment. Lung cancer also have this kind of problem that some lung cancer mutation make it become ‘undruggable’. With the development of the chimeric antigen receptor T cell (CAR-T) therapy, it gives the new way for treating these two kinds of cancer. This essay will focus on three possible target TEM8/ANTXR1, mesothelin and receptor tyrosine kinase–like orphan receptor 1 (ROR1), of the CAR T cell to illustrate whether the CAR T cell therapy could be the way for threating the TNBC and lung cancer in clinical and the potential toxicities of the CAR T cells to the patients.

Citation Download Citation

Jianshi Zhu "The possibility of MSLN, ANTXR1, and ROR1 to become the target of CAR T cell therapy for treating TNBC and lung cancer", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126113G (24 March 2023); https://doi.org/10.1117/12.2669662

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