A study of hypoxia-inducible factor (Hif)-2α, a specific prognostic marker for patients with lung adenocarcinoma

Youkai Yang

doi:10.1117/12.2669376

24 March 2023 A study of hypoxia-inducible factor (Hif)-2α, a specific prognostic marker for patients with lung adenocarcinoma

Youkai Yang

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261145 (2023) https://doi.org/10.1117/12.2669376
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Lung cancer, as calculated, should be the most serious malignant tumors among human diseases, which threatens human life and affects the quality of life. The identification of lung cancer-related biomarkers will aid in the diagnosis and treatment of the disease. In this study, through the analysis of large sample data and the use of biological information websites, it was found that EPAS1 gene, often known as hypoxia-inducible factor (HIF)-2α, is a protein with low tumor tissue-specific expression in pan-cancer analysis. Further investigation into the relationship between HIF-2 expression and lung cancer prognosis revealed that HIF-2 expression is positively correlated with patients' overall survival (OS) time and first progression (FP), making it a useful prognostic marker for lung cancer patients. HIF-2 can also be used as a specific prognostic marker for patients with lung adenocarcinoma (AC).

Citation Download Citation

Youkai Yang "A study of hypoxia-inducible factor (Hif)-2α, a specific prognostic marker for patients with lung adenocarcinoma", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261145 (24 March 2023); https://doi.org/10.1117/12.2669376

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