Effect of drug injection and stimulated learning on trisomic mice expressions of APP and SOD1

Shizhe Zhang

doi:10.1117/12.2669963

24 March 2023 Effect of drug injection and stimulated learning on trisomic mice expressions of APP and SOD1

Shizhe Zhang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126115G (2023) https://doi.org/10.1117/12.2669963
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Trisomy 21, also known as Down's syndrome (DS), is a human genetic disease. It results from an abnormal number of human chromosome 21. Children with Down's syndrome have similarly peculiar facial features and are often associated with a variety of complications and have a much lower life expectancy than the general population. The proteins APP and SOD1 are encoded by the genes on chromosome 21. APP is associated with neurological disorders such as mental retardation caused by Down's syndrome and Alzheimer's disease. Overexpression of SOD1 is associated with muscle atrophy and muscle weakness. A set of available data measured in the Ts65Dn mouse experiment was used in this investigation. Box plots were plotted to observe protein expression levels and the two-way ANOVA was used to test the correlation of protein expression levels with treatment and behavior. In addition, the HSD test indicated the combination of treatment and behavior that had the greatest effect on protein expressions. The results showed that neither memantine nor stimulated learning had a significant effect on APP expression, while memantine and no stimulation of learning resulted in the highest amount of SOD1 expression in trisomic mice.

Citation Download Citation

Shizhe Zhang "Effect of drug injection and stimulated learning on trisomic mice expressions of APP and SOD1", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126115G (24 March 2023); https://doi.org/10.1117/12.2669963

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