Antiviral drugs against influenza viruses: oseltamivir and baloxavir

Shiyun Liang

doi:10.1117/12.2669580

24 March 2023 Antiviral drugs against influenza viruses: oseltamivir and baloxavir

Shiyun Liang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261161 (2023) https://doi.org/10.1117/12.2669580
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Influenza, a recurring seasonal disease, causes over 5 million of illnesses annually worldwide and threatens the health of susceptible groups, including elderly people and children. Although several effective drugs such as neuraminidase inhibitors against influenza viruses have been marketed, the rapid evolution of new variants every flu season and the occurrence of resistant subtypes present a challenge to the prevention and treatment of influenza. This review chooses two representative anti-influenza drugs, oseltamivir (Tamiflu) and baloxavir (Xofluza), elucidating their origin, mode of action, chemical synthesis, and a brief comparison between them is made. Both of the drugs highlight the importance of structure-based design in pharmacy, providing insights in development of a new drug. Other strategies against influenza, including vaccination, are also discussed.

Citation Download Citation

Shiyun Liang "Antiviral drugs against influenza viruses: oseltamivir and baloxavir", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261161 (24 March 2023); https://doi.org/10.1117/12.2669580

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available