Design principle and development of vaccine in COVID-19

Hecong Qin

doi:10.1117/12.2669535

24 March 2023 Design principle and development of vaccine in COVID-19

Hecong Qin

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261162 (2023) https://doi.org/10.1117/12.2669535
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

In the contemporary world, the COVID-19 pandemic has seriously affected the health of people as well as economic development and social stability. Therefore, vaccination to prevent viral infection is an important scientific means to effectively control the epidemic. At present, many countries have developed more and more COVID-19 vaccines with different technology platforms at a record speed, and most of them have been approved for emergency use or be conditionally marketed. In this paper, we mainly reviewed and paid attention to the research progress and achievements related to 8 COVID-19 vaccine technology platforms, including inactivated vaccines, attenuated live vaccines, protein subunit vaccines, virus-like particle (VLP) vaccines, replicated virus vector-based vaccines, non-replicated virus vector-based vaccines, DNA vaccines, and mRNA vaccines. However, with the coming COVID-19 variants, the effectiveness and neutralization activity of the current vaccines, especially the omicron variant, are reduced. Therefore, for the improvement of vaccine effectiveness and safety, we can adopt measures such as developing and optimizing new vaccines such as immune adjuvants or nanoparticle vaccines, and changing inoculation methods such as mixed inoculation and changes in inoculation routes. Finally, we summarized a series of new problems and challenges arising from some COVID-19 vaccines and elaborated some views, hoping to provide some contributions for the development and design of effective strategies for future vaccine development to some extent.

Citation Download Citation

Hecong Qin "Design principle and development of vaccine in COVID-19", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261162 (24 March 2023); https://doi.org/10.1117/12.2669535

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KEYWORDS

COVID 19

Proteins

Antibodies

Nanoparticles

Viruses

Safety

Clinical trials

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