Three classic synthetic paths of fostamatinib and its applications

Yi Shan

doi:10.1117/12.2669629

24 March 2023 Three classic synthetic paths of fostamatinib and its applications

Yi Shan

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126116J (2023) https://doi.org/10.1117/12.2669629
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Tenibs refer to tyrosine kinase inhibitors, which are small molecule drugs. Its role is to block one or more protein kinases, often used in the treatment of tumors, leukemia and other cellular abnormalities of the disease. Fostamatinib is a newly produced substitute drug and mainly used for treating the primary immune thrombocytopenia. It is prominent in the cure of primary immune thrombocytopenia. In addition, it is often used in the treatment of spleen tyrosine kinase (Syk)-related diseases. There is a wide range of market demand, so it is necessary to understand and explore the medicinal properties of fostamatinib. Among them, the synthesis process also plays a very important role. The different structure of fostamatinib has a profound impact on its efficacy. For example, compared with the prodrug salt, the prodrug salt hydrate has more ideal stability characteristics, so it is necessary to further study the synthesis method in order to improve its effect and productivity in industry. In this paper, three synthetic pathways of fostamatinib were analyzed. For example, the synthetic pathway that reacted only for 30 h had the highest efficiency and yielded 37.7%. In addition, this paper also emphasizes the application effect of fostamatinib, including pharmacodynamics and pharmacokinetics, safety and therapeutic potential. Fostamatinib is water-soluble, highly bioavailable, and metabolized in the liver. After two phases of clinical trials, it has been confirmed to be effective in dealing with primary immune thrombocytopenia and has less toxicity. As a new drug, fostamatinib has broad therapeutic potential, which is manifested in the treatment of diseases such as new crown respiratory failure.

Citation Download Citation

Yi Shan "Three classic synthetic paths of fostamatinib and its applications", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126116J (24 March 2023); https://doi.org/10.1117/12.2669629

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Solids

Acetone

Chromatography

Mode conditioning cables

Diseases and disorders

Liver

Solubility

Show All Keywords

Keywords/Phrases

Search In:

Publication Years