Atmospheric pressure operation of a repetitive KrF laser-plasma x-ray source at hv = 1.1 keV

I. C. Edmond Turcu; Fergus O'Neill; Gregory J. Tallents; T. Hannon; Dimitri Batani; Antonio Giulietti; C. W. Wharton; R. A. Meldrum

doi:10.1117/12.20614

1 August 1990 Atmospheric pressure operation of a repetitive KrF laser-plasma x-ray source at hv = 1.1 keV

I. C. Edmond Turcu, Fergus O'Neill, Gregory J. Tallents, T. Hannon, Dimitri Batani, Antonio Giulietti, C. W. Wharton, R. A. Meldrum

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Proceedings Volume 1278, Excimer Lasers and Applications II; (1990) https://doi.org/10.1117/12.20614
Event: The International Congress on Optical Science and Engineering, 1990, The Hague, Netherlands

Abstract

A repetitively pulsed (5Hz) KrF laser-based X-ray source producing photons at i-ru 1.1 keV (copper, L-shell) from a copper coated rotating target has been used to study soft X-ray induced DNA damage effects in Chinese hamster cells. The source was computer controlled for accurate delivery to the biological material of pre-set doses. DNA damage was induced by exposures lasting 7s for V79 cells and 40s for AA8 cells. To minimise the debris from the laser-plasma source and for convenient handling of biological specimens, the target chamber contained helium at 1 atmosphere with a slow flow. The X-ray yield of the source decreased by only at most 10-20% compared to vacuum operation and a further 16% of X-rays were absorbed in helium between target and the biological material placed outside the target chamber behind a beryllium filter. The measured spectral and spatial distribution of the copper X-ray emission was found to be largely independent of the ambient helium pressure. The time resolved X-ray signal lasted for only 3 ns starting at the beginning of the 2lns laser pulse and its shape was independent of helium pressure in the target chamber.

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I. C. Edmond Turcu, Fergus O'Neill, Gregory J. Tallents, T. Hannon, Dimitri Batani, Antonio Giulietti, C. W. Wharton, and R. A. Meldrum "Atmospheric pressure operation of a repetitive KrF laser-plasma x-ray source at hv = 1.1 keV", Proc. SPIE 1278, Excimer Lasers and Applications II, (1 August 1990); https://doi.org/10.1117/12.20614

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