Investigation of DNA methylation in autoimmune diseases with genome-wide association analysis

Jingjing Fan

doi:10.1117/12.2692914

7 September 2023 Investigation of DNA methylation in autoimmune diseases with genome-wide association analysis

Jingjing Fan

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127891G (2023) https://doi.org/10.1117/12.2692914
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Autoimmune diseases are defined as the immune system attacking healthy body tissue that contains self-antigens. Damage of body tissues, malfunctions of organs, and abnormal growth of organs are common symptoms of an autoimmune disease. Although the exact reason causing autoimmune diseases is yet unknown, recent studies suggest that correlations exist between the pathogenesis of autoimmune diseases and epigenetic modifications of DNA. Epigenetic modifications, including methylation of both DNA and histones, have been identified as frequently occurring in individuals with autoimmune diseases. These modifications are thought to be environment-related, which therefore can alter DNA transcription without changing the original DNA sequence. In this review, two systematic (Rheumatoid arthritis and Sjögren syndrome), and two organ-based (Type one diabetes and Hashimoto’s thyroiditis) autoimmune diseases will be discussed. Their association with epigenetic modifications are analysed by twin studies. Several differentially methylated genes and the following signalling pathways that are associated with autoimmune diseases are identified, which may be a potential target for medical treatment.

Citation Download Citation

Jingjing Fan "Investigation of DNA methylation in autoimmune diseases with genome-wide association analysis", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127891G (7 September 2023); https://doi.org/10.1117/12.2692914

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available