Enhanced photodynamic therapy delivery for malignant pleural mesothelioma using 3D-printed models and optical scanning technology

Dennis Sourvanos; Hongjin Sun; Timothy C. Zhu; Andreea Dimofte; Weibing Yang; Theresa M. Busch; Keith A. Cengel; Brook Byrd; Rodrigo Neiva; Joseph P. Fiorellini

doi:10.1117/12.3005184

12 March 2024 Enhanced photodynamic therapy delivery for malignant pleural mesothelioma using 3D-printed models and optical scanning technology

Dennis Sourvanos, Hongjin Sun, Timothy C. Zhu, Andreea Dimofte, Weibing Yang, Theresa M. Busch, Keith A. Cengel, Brook Byrd, Rodrigo Neiva, Joseph P. Fiorellini

Author Affiliations +

Proceedings Volume 12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; 1282309 (2024) https://doi.org/10.1117/12.3005184
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The application of Photodynamic (PDT) for malignant pleural mesothelioma (MSM) is complex due to post-surgery alteration. To address this issue of calculating dose for complex anatomical geometries, our study utilized advanced digital technologies to construct and analyze 3D models of the human lung pleural cavity. This study aims to support a translational model that will eventually enhance PDT dose delivery while minimizing effects on surrounding healthy tissues. The pleural cavity geometries were digitally extracted from medical CT scans, transformed into stereolithography (STL) files, and 3D-printed using acrylic resins. Three volumes corresponding to small, medium, and large patient sizes were prepared. Each model was asymmetrically coated with non-reflective adhesive paper to mimic realistic conditions. Data capture utilized a single handheld scanning device operating at distances to accommodate generalized and refined detail capture. This approach enabled the precise capture of internalized cavity shapes and critical asymmetries. Medical CT validated all 3D printed models. The results confirmed the precise generation and capture of multiple asymmetric 3D human cavity models in actual size. The proposed workflow shows potential for clinicians to accurately map post-surgical pleural cavity changes, thereby improving PDT light dose delivery. This could enhance treatment efficacy and patient outcomes, underlining the potential of digital technology in advancing precision oncology and integration into future clinical practice.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Dennis Sourvanos, Hongjin Sun, Timothy C. Zhu, Andreea Dimofte, Weibing Yang, Theresa M. Busch, Keith A. Cengel, Brook Byrd, Rodrigo Neiva, and Joseph P. Fiorellini "Enhanced photodynamic therapy delivery for malignant pleural mesothelioma using 3D-printed models and optical scanning technology", Proc. SPIE 12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, 1282309 (12 March 2024); https://doi.org/10.1117/12.3005184

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available