Mid-infrared photoacoustic stimulation of neurons through vibrational excitation in polydimethylsiloxane

Zhiyi Du; Mingsheng Li; Guo Chen; Maijie Xiang; Danchen Jia; Ji-Xin Cheng; Chen Yang

doi:10.1117/12.3003119

13 March 2024 Mid-infrared photoacoustic stimulation of neurons through vibrational excitation in polydimethylsiloxane

Zhiyi Du, Mingsheng Li, Guo Chen, Maijie Xiang, Danchen Jia, Ji-Xin Cheng, Chen Yang

Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 128290K (2024) https://doi.org/10.1117/12.3003119
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Photoacoustic (PA) neural modulation has gained attention for its non-genetic, precise, and minimally damaging properties. Existing PA methods relay on thermal expansion of the absorber/ elastomer matrix. Usually, a visible or near-infrared (NIR) laser is used to excite the electronic transition of the absorber. Here, we present a mid-infrared photoacoustic (MIPA) emitter through vibrational excitation in polydimethylsiloxane (PDMS). A transparent film with 37.5 times enhancement of PA performance compared to carbon nanotube based PA emitter is obtained due to bypass the thermal conduction process. Both wide-field (100μm) and single cell MIPA neural stimulation were achieved and validated through calcium imaging.

Citation Download Citation

Zhiyi Du, Mingsheng Li, Guo Chen, Maijie Xiang, Danchen Jia, Ji-Xin Cheng, and Chen Yang "Mid-infrared photoacoustic stimulation of neurons through vibrational excitation in polydimethylsiloxane", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 128290K (13 March 2024); https://doi.org/10.1117/12.3003119

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