Synthesis and characterization of antibody-conjugated gold nanoparticles for biological applications

Adi Anaki; Tamar Sadan; Menachem Motiei; Rachela Popovtzer

doi:10.1117/12.3003097

13 March 2024 Synthesis and characterization of antibody-conjugated gold nanoparticles for biological applications

Adi Anaki, Tamar Sadan, Menachem Motiei, Rachela Popovtzer

Proceedings Volume 12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI; 1285809 (2024) https://doi.org/10.1117/12.3003097
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Gold nanoparticles (GNPs) have garnered significant attention in biomedical applications, particularly as versatile platforms for drug delivery and targeted therapy. The conjugation of GNPs with antibodies offers a promising strategy to enhance their specificity and efficacy in various therapeutic approaches. In this study, we focus on synthesizing different types of GNPs conjugated with antibodies and investigate the influence of various synthesis methods on nanoparticle characterization. The results demonstrated that different synthesis methods lead to different degrees of antibody conjugation on the GNP surface and to varied efficiency on biosystems. This work has the potential to outline design principles that could positively affect the development of targeted nanotherapeutics for various biomedical applications.

Citation Download Citation

Adi Anaki, Tamar Sadan, Menachem Motiei, and Rachela Popovtzer "Synthesis and characterization of antibody-conjugated gold nanoparticles for biological applications", Proc. SPIE 12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI, 1285809 (13 March 2024); https://doi.org/10.1117/12.3003097

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