Design of coronary artery phantom using polyvinyl alcohol cryogel for optical coherence tomography imaging in Kawasaki disease

Matilde Pazzaglia; Atefeh Abdolmanafi; Gerardo Tibamoso-Pedraza; Nagib Dahdah; Luc Duong

doi:10.1117/12.3006698

29 March 2024 Design of coronary artery phantom using polyvinyl alcohol cryogel for optical coherence tomography imaging in Kawasaki disease

Matilde Pazzaglia, Atefeh Abdolmanafi, Gerardo Tibamoso-Pedraza, Nagib Dahdah, Luc Duong

Author Affiliations +

Proceedings Volume 12928, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling; 1292808 (2024) https://doi.org/10.1117/12.3006698
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

Kawasaki disease, a childhood pathology, is marked by the potential for coronary artery complications, which can lead to the dilation or inflammation of the blood vessel wall if left untreated. Intravascular Optical coherence tomography (IVOCT) was introduced for intravascular imaging of coronary arteries to provide valuable navigation guidance information to cardiologists. It requires a skilled operator, and the acquisition protocol is complex. The goal of this study is to present a framework to reproduce patient specific coronary OCT phantoms using polyvinyl alcohol cryogel (PVA-c), which can be used for training cardiologists and for better understanding of the OCT image formation process. This innovative approach enables us to produce phantoms with both mechanical and optical properties very similar to human tissue. To produce these phantoms, we design and print in 3D modular cylindrical molds from real OCT arterial images. A mixture of PVA is poured into the molds and submitted to three thaw and freeze cycles to create soft tissue that represent coronary arteries affected by Kawasaki disease. Once the phantoms have been created, OCT pull-back sequences are acquired and compared to the original images. We acknowledged that our PVA-c phantoms reproduces morphological shape and visual appearance on OCT very similar to human tissue. This holds true even when applied to extremely small morphologies.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Matilde Pazzaglia, Atefeh Abdolmanafi, Gerardo Tibamoso-Pedraza, Nagib Dahdah, and Luc Duong "Design of coronary artery phantom using polyvinyl alcohol cryogel for optical coherence tomography imaging in Kawasaki disease", Proc. SPIE 12928, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling, 1292808 (29 March 2024); https://doi.org/10.1117/12.3006698

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