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Integrated Optic waveguide-based sensors are promising solutions for various applications, notably in the label-free detection of chemical and biological substances. For optimal sensitivity, the guided mode should interact with biomaterial. In this proposed work, we have considered Hollow-core waveguides and Strip waveguide-based biosensors. Hollow-core waveguides are analyzed as optofluidic devices in which bio-analytes form the core. Guiding light within a hollow-core optofluidic waveguide involves confining it to a region of higher refractive index, enclosed by cladding material of lower refractive index. Strip waveguide - Silicon on Insulator (SOI) has been considered for simulation purposes. Bulk sensing and Surface sensing scheme mechanisms were used to study the variations when bio analyte was encountered with waveguide material. In this article, we have modeled, simulated, and analyzed two types of waveguides viz., Optofluidic channel with biomaterial as core, bulk sensing with biomaterial as clad covering the Silicon strip waveguide, and surface sensing with biomaterial covering the surface of the waveguide. Optofluidic channel with sensitivity in the range of 2.4*10 -2 /RIU to 2.8*10 -2 /RIU; Bulk sensing sensitivity in the range of 2.5*10 -1 /RIU to 3.7*10 -1 /RIU; Surface sensing sensitivity in the range of 1.96*10 -2 /RIU to 2.9*10 -3 /RIU for different biomaterials. We here observed results and limitations for design guidelines. Our findings would assist in choosing an appropriate platform and optimizing sensitivity by the effective refractive index for the given bio applications
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