Effect of coagulation on laser light distribution in myocardial tissue

Ramtin Agah; Devang Sheth; Massoud Motamedi

doi:10.1117/12.44032

1 May 1991 Effect of coagulation on laser light distribution in myocardial tissue

Ramtin Agah, Devang Sheth, Massoud Motamedi

Proceedings Volume 1425, Diagnostic and Therapeutic Cardiovascular Interventions; (1991) https://doi.org/10.1117/12.44032
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

The changes in total reflection and transmission of porcine myocardium due to thermal coagulation were measured during tissue heating in a temperature-controlled water bath, at different temperature ranging between 54 degree(s)-63 degree(s)C. At 633 nm, the measurements yield a picture of continuous decrease in transmission and a peak with a subsequent fall (approximately 10% from the peak) in reflection measurements of the tissue during coagulation process. Utilizing these measurements and an inverse solution to the radiative transfer equation, the optical properties of tissue, absorption, (mu)_a, and effective scattering, (mu)_s=(mu)_s(1-g) were calculated. A one-dimensional diffusion approximation was used to demonstrate the effects of thermally induced changes in the optical properties of tissue on light distribution in tissue. The pattern of changes in (mu)_a and (mu)_s seem to indicate that several simultaneous rate processes may be responsible for tissue coagulation. A postulate is put forward to use one such rate process to characterize threshold thermal damage to porcine myocardium and the accompanying protein denaturation.

Citation Download Citation

Ramtin Agah, Devang Sheth, and Massoud Motamedi "Effect of coagulation on laser light distribution in myocardial tissue", Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); https://doi.org/10.1117/12.44032

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