Photosensitized receptor inactivation with He-Ne laser: preliminary results

Simon Arber; William Zev Rymer; David Crumrine

doi:10.1117/12.44132

1 May 1991 Photosensitized receptor inactivation with He-Ne laser: preliminary results

Simon Arber, William Zev Rymer, David Crumrine

Proceedings Volume 1428, Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences; (1991) https://doi.org/10.1117/12.44132
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Receptor inactivation by means of chromophore-conjugated receptor ligands and laser is discussed. The results of preliminary experiments aimed at inactivation of FMRFamide receptors in snail neurons using a He-Ne laser and FMRFamide analogs conjugated with Azure B are presented. Because the conjugates synthesized apparently bound to another class of binding sites on the neuronal membrane, the FMRFamide receptor inactivation was not achieved. However, laser inactivation was demonstrated for the conjugate binding sites.

Citation Download Citation

Simon Arber, William Zev Rymer, and David Crumrine "Photosensitized receptor inactivation with He-Ne laser: preliminary results", Proc. SPIE 1428, Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences, (1 May 1991); https://doi.org/10.1117/12.44132

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