Phthalocyanines as phototherapeutic agents for tumors

Giulio Jori; Elena Reddi; Roberta Biolo; Laura Polo; Giuliana Valduga

doi:10.1117/12.48199

1 November 1991 Phthalocyanines as phototherapeutic agents for tumors

Giulio Jori, Elena Reddi, Roberta Biolo, Laura Polo, Giuliana Valduga

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48199
Event: MedTech '91, 1991, Berlin, Germany

Abstract

Zn(II)-phthalocyanine (ZnPc) is a tetraazaisoindole pigment which can be prepared by chemical synthesis with a high degree of purity, and it efficiently absorbs 680 nm of light. These properties, associated with its ability to generate activated oxygen species (e.g., singlet oxygen) upon photoexcitation, make ZnPc a potential phototherapeutic agent. Actually, upon delivery of ZnPc to tumor-bearing animals after incorporation into liposomal vesicles, the dye was uptaken and retained by the tumor tissue in significant amounts and with a good degree of selectivity. Irradiation of the ZnPc-loaded tumor area with ca. 680 nm of light caused tumor necrosis to an extent which was related to the dye concentration in the tumor.

Citation Download Citation

Giulio Jori, Elena Reddi, Roberta Biolo, Laura Polo, and Giuliana Valduga "Phthalocyanines as phototherapeutic agents for tumors", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48199

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