Hematopoietic stimulation by porphyrin photosensitizers (Invited Paper)

Julia G. Levy; David W. C. Hunt; David W. Mitchell; Catriona H. M. Jamieson

doi:10.1117/12.60929

1 June 1992 Hematopoietic stimulation by porphyrin photosensitizers (Invited Paper)

Julia G. Levy, David W. C. Hunt, David W. Mitchell, Catriona H. M. Jamieson

Proceedings Volume 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy; (1992) https://doi.org/10.1117/12.60929
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

The effects of the photosensitizers, PhotofrinTM and benozoporphyrin derivative monoacid ring A (BPD) on a variety of hematopoietic cell functions have been studied, both in the presence and absence of light activation. A marked increase in hematopoiesis was observed in the bone marrow and spleens of DBA/2 mice administered high dose Photofrin but not BPD. This was manifested in an increased relative spleen weight, nucleated spleen cell number and circulating white blood cell concentration 7 days following Photofrin injection. We have shown that BPD and light doses just below phototoxic ranges stimulate the growth of human colony forming committed myeloid progenitors as well as pluripotent stem cells grown in long term marrow culture. Studies on the effect of BPD on the function of T lymphocytes in the absence of light has also demonstrated a stimulatory effect. The dose range in which this is observed is considerably broader than that observed with light activation. The mechanisms involved in this stimulatory effect have been studied and are discussed.

Citation Download Citation

Julia G. Levy, David W. C. Hunt, David W. Mitchell, and Catriona H. M. Jamieson "Hematopoietic stimulation by porphyrin photosensitizers (Invited Paper)", Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); https://doi.org/10.1117/12.60929

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