Light dosage in whole bladder wall photodynamic therapy at 532 and 630 nm

Hugo J. van Staveren; Joost W.H. Ramaekers; Johannes P. A. Marijnissen; Johan F. Beek; Marleen Keijzer; Willem M. Star

doi:10.1117/12.168715

1 March 1994 Light dosage in whole bladder wall photodynamic therapy at 532 and 630 nm

Hugo J. van Staveren, Joost W.H. Ramaekers, Johannes P. A. Marijnissen, Johan F. Beek, Marleen Keijzer, Willem M. Star

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168715
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

The optical absorption, scattering and anisotropy coefficient of piglet and diseased human bladder tissue were determined in vitro in the wavelength range of 500 - 650 nm. Monte Carlo simulations for whole bladder wall (WBW) photodynamic therapy (PDT) have been performed using the optical parameters determined in vitro. The calculated light dose rate values are in agreement with those measured in clinical WBW-PDT, previously performed at 630 nm. The light dose rate at the bladder wall can differ by a factor of 4, due to variations in optical properties of the tissue. This demonstrates the necessity of in situ light dosimetry during clinical WBW-PDT. WBW-PDT with red light (630 nm) will be technically more advantageous than with green light (532 nm), because of a higher integrating sphere effect.

Citation Download Citation

Hugo J. van Staveren, Joost W.H. Ramaekers, Johannes P. A. Marijnissen, Johan F. Beek, Marleen Keijzer, and Willem M. Star "Light dosage in whole bladder wall photodynamic therapy at 532 and 630 nm", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168715

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