Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty

Keith L. March; Tony J. Spaedy; Michael Aita; Robert L. Wilensky; Ionina Gradus-Pizlo; David R. Hathaway

doi:10.1117/12.179923

12 July 1994 Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty

Keith L. March, Tony J. Spaedy, Michael Aita, Robert L. Wilensky, Ionina Gradus-Pizlo, David R. Hathaway

Author Affiliations +

Proceedings Volume 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV; (1994) https://doi.org/10.1117/12.179923
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Smooth muscle cell proliferation plays a major role in restenosis following angioplasty. We have studied the effects of ultraviolet A (UVA) activation of 8-methoxypsoralen (8-MOP) on cultured SMC as well as atherosclerotic rabbit femoral arteries following angioplasty. 8-MOP and UVA display synergistic proliferation inhibition of cultured SMC in a cell-cycle independent manner. At intermediate doses, a cytostatic effect was seen over a 28 day period following a single exposure. In conclusion, a combination of 8-MOP and UVA significantly lowered SMC proliferation and cellularity in cell culture as well as in the neointima and media after balloon-induced vascular injury in the atherosclerotic rabbit model. This approach of systemic administration and local activation is feasible and offers a potential therapy for restenosis.

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Keith L. March, Tony J. Spaedy, Michael Aita, Robert L. Wilensky, Ionina Gradus-Pizlo, and David R. Hathaway "Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty", Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); https://doi.org/10.1117/12.179923

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